A Systematic review of Inflammatory biomarkers, Clinical significance, Detection, and their therapeutic agents
Diabetomics Medical Private Limited, Muppireddypally Village, Medak - 502336, Telangana, India.
Review
World Journal of Biology Pharmacy and Health Sciences, 2024, 17(03), 242–251.
Article DOI: 10.30574/wjbphs.2024.17.3.0137
Publication history:
Received on 09 February 2024; revised on 16 March 2024; accepted on 19 March 2024
Abstract:
Biomarkers in inflammation are measurable and valuable biological indicators that can be used to assess the severity, presence, progression of inflammatory processes within the body. Inflammation is a complex physiological response that occurs in response to various stimuli, such as tissue damage, infections, and autoimmune reactions. There are several types of biomarkers Cytokines, Eicosanoids, Calprotectin, E-selectin, P-selectin, Fibrinogen, C-reactive protein (CRP), Exosomes, Myeloperoxidase (MPO), Chemokines , Neurofilament light chain (NfL), MMPs, 8-isoPGF2α, TIMPs, cell NO2-, adhesion molecules, PTX3, autoantibodies, complements, sRAGE, NT-proBNP, acute-phase and immunology-related proteins, thrombogenicity markers, ghrelin, leptin and adipokines, Presepsin, p75ECD, phosphorylated neurofilament heavy (pNfH), IDO1 and TARC, SCCA2, CTACK, EDN, MDC, LDH, and commonly used in the context of inflammation. We analysed the literature through online databases such as PubMed ScienceDirect and Google Scholar were used to search for journals and studies published. In this review, we discuss about different types of biomarkers involved in inflammation and their levels of elevation in various disease conditions. Quantified inflammatory biomarkers are effective clinical strategy for correct and reasonable drug treatment. There may have been advancements in the development of new treatments or therapies since my last update. Therapeutic agents like colchicine can modulate the immune response to reduce inflammation.
Keywords:
Biomarkers; Inflammation; Exosomes; Cytokines; Interleukin
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